| 2021-09-05 10:00:545. 9. 2021 | TJ Spartak Soběslav  | 0 - 3 |  FK Protivín “D-st” |
| 2021-09-11 10:00:4311. 9. 2021 | FK Protivín “D-st” | 2 - 0 |  1. FC Jistebnice |
| 2021-09-19 14:00:1519. 9. 2021 | TJ Spartak Trhové Sviny  | 0 - 3 | FK Protivín “D-st” |
| 2021-09-25 10:00:2525. 9. 2021 | FK Protivín “D-st” | 3 - 3 |  SK KAVAS Větrovy |
| 2021-10-03 10:00:223. 10. 2021 | FK Olympie Týn nad Vltavou  | 2 - 5 | FK Protivín “D-st” |
| 2021-10-09 10:00:539. 10. 2021 | FK Protivín “D-st” | 3 - 2 |  TJ Centropen Dačice |
| 2021-10-17 10:00:0417. 10. 2021 | TJ Sokol Planá n. L.  | 0 - 3 | FK Protivín “D-st” |
| 2021-10-23 10:00:2423. 10. 2021 | FK Protivín “D-st” | 10:00:2410:00 |  SK SIKO Čimelice |
| 2021-10-30 10:00:5530. 10. 2021 | FK Protivín “D-st” | 10:00:5510:00 |  TJ Hradiště B |
