| 2021-08-07 17:00:547. 8. 2021 | SK SIKO Čimelice  | 1 - 2 |  FK Protivín “A” | Report |
| 2021-08-14 15:00:4314. 8. 2021 | FK Protivín “A” | 1 - 4 |  Č. Krumlov | Report |
| 2021-08-22 17:00:2522. 8. 2021 | SK Jankov  | 2 - 0 | FK Protivín “A” | Report |
| 2021-08-28 15:00:2228. 8. 2021 | FK Protivín “A” | 2 - 2 |  FK Olešník | Report |
| 2021-09-04 15:00:564. 9. 2021 | FK Protivín “A” | 0 - 0 |  TJ Dražice | Report |
| 2021-09-12 17:00:1012. 9. 2021 | FC ZVVZ Milevsko  | 2 - 0 | FK Protivín “A” | Report |
| 2021-09-18 10:15:1718. 9. 2021 | FK Protivín “A” | 1 - 3 |  TJ Osek | Report |
| 2021-09-25 16:30:4725. 9. 2021 | SK Rudolfov  | 1 - 2 | FK Protivín “A” | Report |
| 2021-09-28 15:00:2928. 9. 2021 | FK Protivín “A” | 1 - 0 |  FK Junior Strakonice | Report |
| 2021-10-02 15:00:002. 10. 2021 | FK Protivín “A” | 0 - 1 |  FK Jiskra Třeboň | Report |
| 2021-10-09 15:30:299. 10. 2021 | FK Olympie Týn nad Vltavou  | 3 - 1 | FK Protivín “A” | Report |
| 2021-10-16 15:00:1916. 10. 2021 | FK Protivín “A” | 7 - 1 |  Sokol Sezimovo Ústí | Report |
| 2021-10-23 10:15:4323. 10. 2021 | FC MAS Táborsko B  | 10:15:4310:15 | FK Protivín “A” | Report |
| 2021-10-30 14:00:3330. 10. 2021 | FK Protivín “A” | 14:00:3314:00 |  FK Tatran Prachatice | Náhled |
